CAFFEINE CONTRACTURE

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The Relationship between Caffeine Contracture of Intact Muscle and the Effect of Caffeine on Reticulum

At concentrations between 1 to 10 mM, caffeine reduced the Ca-accumulating capacity of fragmented reticulum obtained from frog and rabbit muscle. With 8 mM caffeine enough Ca was released from frog reticulum to account for the force of the contracture. Caffeine did not affect all reticulum membranes equally. The fraction which was spun down at 2000 g was more sensitive than the lighter fraction...

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Caffeine contracture in frog cardiac muscle after exposure to high concentrations of calcium.

Caffeine induced contracture in frog auricular muscle at room temperature when the muscle was exposed to a Ca-rich solution. The initial transient tension lasted 10-30 sec, and it was inhibited by procaine. It was dependent on caffeine concentration and the time of exposure to a Ca-rich solution prior to caffeine attack, but was little dependent on Ca concentration during caffeine contracture.

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Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.

Malignant hyperthermia (MH) is a pharmacogenetic disease triggered by volatile anesthetics and succinylcholine. Deaths due to MH have been reported in Brazil. The first Malignant Hyperthermia Diagnostic and Research Center in Latin America was inaugurated in 1993 at the Federal University of Rio de Janeiro, Brazil. The center followed the diagnostic protocols of the North America MH Group, in w...

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Dupuytren's Contracture

DESCRIPTION Patient is a 65-year-old right-hand-dominant man. He presents with a 15-year history of progressive left small finger contracture with occasional palmar pain. On examination, he has a palpable palmar cord. Contraction of left small finger metacarpophalangeal (MP) joint was noted to be 60 • .

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Dupuytren's contracture.

The disease is often genetic and may indicate that you have Viking ancestry! It is commoner in males and in people that are diabetic, epileptic, who have liver disease or those who have injured the hand. Both alcohol consumption and smoking increase the risk of its appearance. Its progression is unpredictable but its appearance at an early age (<40years), particularly if there is a strong famil...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1960

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.46.6.897